Pharmacological manipulation of the complement system in human diseases
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چکیده
منابع مشابه
Pharmacological manipulation of the complement system in human diseases.
Complement is one of the powerful effector systems involved in the body's defense. When present in a dormant state it can, in concert with other components of immune system, protect the individual from foreign pathogens. However, inappropriately activated complement can cause disease. Several disease states such as immune complex and autoimmune diseases and deficiencies of some complement regul...
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There is evidence in sepsis, both in rodents and in humans, that activation of the complement system results in excessive production of C5a, which triggers a series of events leading to septic shock, multiorgan failure, and lethality. In rodents following cecal ligation and puncture (CLP), which induces polymicrobial sepsis, in vivo blockade of C5a using neutralizing antibodies dramatically imp...
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ژورنال
عنوان ژورنال: Frontiers in Bioscience
سال: 1996
ISSN: 1093-9946,1093-4715
DOI: 10.2741/a139